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Clin Pharmacol Ther 103:971974 Hua Z, Liu L, Shen J, Cheng K, Liu A, Yang J, Wang L, Qu T, Yang H, Li Y (2016) Mesenchymal stem cells reversed morphine tolerance and opioid-induced hyperalgesia

For most people taking B12 at standard supplemental doses as part of a well-formulated multivitamin, this isn't a concern

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