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Description
Through MT2 receptor stimulation, melatonin causes a cascade of downstream activation of protein kinase C (PKC), phosphorylation, and inactivation of GSK-3 leading to the reduction of tau hyperphosphorylation (Shi et al., 2018)
Then both solutions were mixed in volume ratio 1:1
This paradoxical effect underscores the importance of careful dosing in therapeutic applications
Gene [Internet]
EU IGFD Registry Study Group
