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Cerebellum (2011) 10:438 10.1007/s12311-010-0223-4 [DOI] [PubMed] [Google Scholar] 108.Adams JB, Audhya T, McDonough-Means S

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The pathway imbalance is hypothesized to have distinctive behavioral and circuit-level implications: high D1/D2 receptor ratio results in low D2R activation and weak suppression of GABAergic transmission from D2 SPNs, which in turn causes a strong lateral inhibition onto D1 SPNs 45,58 , promoting risk-avoidance phenotype 44