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Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts
Numerous mechanisms contribute to this action, including the reduction of ROS generation and the encouragement of Nrf2 nuclear translocation, which increases heme oxygenase-1 (HO-1) expression and lowers oxidative stress [175,176,177]
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Additionally, RB1 deficiency is able to enhance tumor metastasis by increasing OXPHOS to generate more ATP fueling for tumor invasion and cooperating oncogenic alterations to uphold EMT and metastasis (232)
