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GLP-1 peptide Cagrilintide works by activating amylin receptors instead of GLP-1 pathways, which makes its metabolic actions more balanced

211 SongH.McEwanP.Ameen-AliK.TomasevichA.Kennedy-DietrichC.PalmaA.et al (2022)

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Macrophages Are Recruited to Hypoxic Tumor Areas and Acquire a Pro-angiogenic M2-Polarized Phenotype via Hypoxic Cancer Cell Derived Cytokines Oncostatin M and Eotaxin

Although the study did not meet the expected goals, the addition of bevacizumab to chemotherapy increased the mPFS and ORR of the first-line treatment of GC, and also showed geographical differences, with the greatest survival benefit in American patients and almost no survival benefit in Asian patients