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Thus, CD38 plays a beneficial role in the recovery of CHI of mice, and this effect is mediated, at least in part, by an increase in the number of microglia/macrophages, mediated by CD38 ( Effect of CD38 on Macrophage Function and Its Possible Mechanisms Effect of CD38 on the Intracellular Calcium Concentration of Macrophages CD38 is a regulator of the intracellular calcium pool and has the characteristics of anti-osteoclastogenesis

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This therapeutic approach demonstrated increased median long-term survival with sustained remission in 5080% of mice with marginal toxicity at a single dose (2445 Ci

doi: 10.1046/j.1467-789x.2001.00040.x