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Second, in addition, decreased cellular cholesterol concentration in all cells upregulates the transcription of the LDL receptor gene, and LDL receptor expression on the cell surface

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Subsequent addition of cellular cholesterol to the HDL particle occurs in a number of tissues through the action of another ATP-binding cassette transporter 1 (ABCG1) and scavenger receptor class BI (SR-BI), molecules that prefer larger HDL as acceptors (Fig

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