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Functions in the GI tract Prosecretory action of VIP VIP released from enteric nerves stimulates anion secretion from the enterocytes via G s -coupled VPAC1 activation 58 , followed by adenylyl cyclase activation, increased intracellular cAMP, protein kinase A (PKA) activation, and cystic fibrosis transmembrane conductance regulator (CFTR) activation 46, 59

ATRA, conjugated with disulfide bond (-SS-) to form ATRA-SS-ATRA, demonstrates good self-assembly behavior 48,49,50 , allowing it to load the hydrophobic PS-CHO and create a nan-prodrug (PS-CHO@ATRA-SS-ATRA)