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Second, limitations inherent to animal models constrain the translational relevance of current findings

beta-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling

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Gorgey, A.S., O

[24] This complex is too large to cross the capillary endothelium freely, so it functions as a slowly releasing circulating reservoir: it prolongs the systemic presence of IGF-1 while simultaneously keeping the bulk of it biologically restrained until it is handed off to tissues
