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Melatonin, the primary hormone of the pineal gland, is a powerful "chronobiotic" that helps maintain the body's normal circadian rhythms.* In individuals who have difficulty sleeping or who have altered circadian rhythms because of jet lag or night shift work, melatonin supplementation promotes the resynchronization of this cycle.* Supplementation can also benefit those whose difficulty sleeping is caused by the aging-related decrease in the body's ability to synthesize melatonin from the amino acid tryptophan.* Research indicates melatonin exerts its sleep-promoting efficacy by decreasing the amount of time needed to fall asleep, by promoting the ability to stay asleep, and by enhancing the depth of sleep.*

(3) cAMP is an essential intracellular messenger molecule involved in transmitting signals from various extracellular stimuli into intracellular responses

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The fibrinogen levels decreased significantly from day 1 to 14 in both the LCLT and placebo groups ( p = 0.003, p = 0.048, respectively)