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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs

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Overall 86.0% subjects used basal insulin analogues, 93.5% fast-acting analogues, 7.3% premixed insulins, 0.9% regular human insulin, and 0.6% NPH