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Excessive secretion of glutamate can cause severe damage to neurons and HCs, leading to ARHL

This mechanism suggests that effective therapies may require intracellular delivery and interruption of cell-to-cell transmission, both of which present substantial delivery challenges (Lasagna-Reeves et al., 2012

In addition to improving insulin sensitivity, metformin also appears to promote healthy fat distribution, which is typically deregulated in HAART-treated HIV patients

Mesenchymal stem cells in treatment of spinal cord injury and amyotrophic lateral sclerosis