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Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients

Mitochondrial dysfunction due to a relative lack of micronutrients and substrates like carnitines is implicated in the development of many chronic diseases and neurodegenerative diseases

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Vaughan RA, Garcia-Smith R, Bisoffi M, Trujillo KA, Conn CA (2012) Effects of caffeine on metabolism and mitochondria biogenesis in rhabdomyosarcoma cells compared with 2,4-dinitrophenol

For CTL1, the pH assays are done at concentrations matching the first reported K m (1 M for tCTL1) but below the later reported K m for human CTL1 of 10 M (22, 27)