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The most common cause is insufficient intake due to malnutrition or especially in those following strict vegetarian or vegan diets because B12 primarily comes from animal sources

Considering aspartate is mainly synthesized in the mitochondrial matrix through tricarboxylic acid cyle 89 , MOTS-c might be involved in regulating mitochondrial aspartateglutamate metabolism

If cortisol dysregulation or anxiety is the primary sleep disruptor, Selank may be the first-line intervention