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Description
deficiency that seems to be present in FM patients might be a promising therapeutic target for CNS imbalances in them, although further research is needed
Despite the limited biosynthesis capability of the RBC, some endogenous GSH is still synthetized in the cytosol through two ATP-dependent reactions catalyzed by two different enzymes, glutamate cysteine ligase and glutathione synthase [13]
When this pathway is less efficient, glutathione demand often exceeds supply
By coupling brain-targeted nanocarriers with patient-specific metabolic fingerprints, a gene-matched, pathway-matched strategy is emergingpositioning riboflavin at the center of personalized, systems-level interventions for both rare flavoproteinopathies and common neurodegenerative disorders
[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Kularatne R.N., Bulumulla C., Catchpole T., Takacs A., Christie A., Stefan M.C., Csaky K.G
