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The induction of melatonin synthesis in rodents and human macrophages by the transcription factor is a hallmark in inflammatory responses and inflammation ( During the mounting of an innate immune response melatonin plays various roles: the reduction of nocturnal melatonin leads to the mobilization of leukocytes from the bone marrow to the blood, and from the blood to the site of lesion

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RNA sequencing (RNA-seq) and data analysis Total RNA was extracted from cultured astrocytes using RNeasy mini kit (Qiagen)

TFR1 recently has been introduced as a specific ferroptosis marker ( 3+ is reduced to Fe 2+ by the ferrireductase activity of six-transmembrane epithelial antigens of the prostate 3 (STEAP3) in the endosome (Knutson, 2007)

Statistical analysis Data are presented as mean SD in Table I and mean SEM in Figure 1