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10.1016/j.ab.2016.12.022 7
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148 PatelD.RathinamM.JarvisC.MahimainathanL.HendersonG.NarasimhanM

Elevation of intracellular Ca 2+ activates scramblase to ensure PS externalization, opens the Gardos channels, resulting in K + efflux and subsequent cell shrinkage, and mobilizes calpain, leading to cytoskeleton degradation and membrane microvesiculation [78]

Importantly, MSC-EVs possess the unique ability to cross biological barriers, such as the blood-brain barrier, broadening their therapeutic potential
