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While the majority of gastric enteric neurons receive vagal innervation, there is only a relatively minor contribution of vagal efferent inputs to the distal intestine and colon, both structurally and functionally [10]

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A four-week hold is roughly the window needed for a step to reach steady state and for the gut to adapt to it, which is why escalating before the block is complete effectively means judging a dose you have not yet fully experienced

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