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Since cysteine is known to be neurotoxic in excessive amounts [32], treatment with N-acetylcysteine should not be recommended for patients with glutathione synthetase deficiency as this may increase the intracellular cysteine levels even more

Due to the nature of gastric bypass surgerythe intestinal tract is modified or diverted, less space is left in the stomach for calorie absorption, but also for the absorption of nutrients like vitamin B12

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In addition, the mechanism of detoxification by GSTD2 was revealed via its strong affinity towards isothiocyanate and catalysis of the conjugation between GSH and isothiocyanate

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