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Microvascular complications are equally driven by oxidative damage i.e., in diabetic retinopathy, ROS-induced VEGF overexpression through HIF-1 stabilization leads to pathological angiogenesis (Kowluru and Mishra, 2017), while in diabetic nephropathy, podocyte injury results from NOX4-derived O 2 and mitochondrial ROS-mediated apoptosis (Jha et al., 2024)

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