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The structural similarity between IGF1R and the insulin receptor means LR3 can be used to probe questions about cross-receptor signaling and the metabolic effects of IGF axis activation

Accumulation with age of vesicular GTPases involved in endocytosis (Rab7) and lysosomal degradation (Arl8b) Small GTPases drive essential processes to clear aggregated or misfolded proteins in the cell by the process of autophagy [7]

doi: 10.21037/apm-20-1649 62 HebbelRPBelcherJDVercellottiGM
Wang Y, Wu S, Li Q, Sun H, Wang H (2023) Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes