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The expression and activation of YAP and YY1 in the endothelium is triggered by shear stress alterations, and both TFs exert pro-atherogenic effects in vivo, which [43, 44] could be further enhanced by lactylation

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The result is a half-life extension to 2472 hours making PEG-MGF the standard in vivo-capable form of the MGF E-peptide in all pre-clinical research requiring sustained systemic exposure, time-course pharmacokinetic studies, or repeated-dosing paradigms