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Description
The mechanism of itaconate-mediated inhibition of these enzymes is via alkylation of cysteine residues as well as by acylation of lysine residues
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Ferroptosis, a new form of cell death: Opportunities and challenges in cancer
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TambaraALde Los Santos MoraesLDal FornoAHBoldoriJRGonalves SoaresATde Freitas RodriguesCet al
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[1] Despite being non-essential, glycine plays critical roles in normal physiology
It has been more commonly documented with intravenous NAC (used in clinical settings for paracetamol overdose), where allergic-type reactions such as flushing and rash occur in a small proportion of patients (Memorial Sloan Kettering)