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The development of a biomimetic scaffold comprises different aspects, such as the fabrication technique, which determines the macro- and microarchitecture of the scaffold, the material used for scaffold fabrication and the inclusion within the scaffold of bioactive molecules or other stimulating factors to promote the formation of a functional tissue (Figure 1)

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For acute injuries with significant pain, split dosing may offer advantages

GI symptoms that persisted through titration often resolve or become so mild they are barely noticeable