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Diet and sleep come first

Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all

One 8-week study (n = 13) found a large effect size (d = 1.616) in reducing repetitive behaviors, as measured by the C-YBOCS (185), while a 12-week trial (n = 27) showed significant improvement in irritability on the Aberrant Behavior Checklist-Irritability subscale and Clinical Global Impression-Improvement scale (186)
Therefore, by understanding the root pathophysiology of ME/CFS, not only may chances of recovery be increased, but also it may be possible to avoid the crash altogether