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Jewish Telegraphic Agency
In addition, competition experiments with excess amount of SLF fully rescued from degradation, confirming the requirement of FKBP12 target engagement for productive degradation (Supplementary Fig
10.1038/35030000 38 Coutos-ThevenotP.MaesO.JouenneT.Claude MauroM.BoulayM.DeloireA.et al
Consistent with negative feedback by p21 on p53 levels (Broude et al, 2007), induction of p21 FL and p21 N , but not p21 C , decreased basal p53 levels and attenuated p53 stabilization upon nutlin-3 treatment, further validating the function of these proteins (Fig 2E)
This can cause less nutrient absorption
