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In neuronal cell models (SH-SY5Y neurons and BV2 microglia), PS-NPs elicited neuroinflammatory responses and multiple forms of cell death responses, including mitochondrial dysfunction, ferroptosis, apoptosis, and pyroptosis

2.3.2 Non-histone protein modifications Beyond histone modifications, other pivotal protein modifications, including phosphorylation, acetylation, and ubiquitination, play crucial roles in regulating cellular apoptosis, DNA repair, inflammatory responses, and intestinal barrier function to confer protective effects

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Examples of such peptides include: MOTS-c: MOTS-c is a naturally occurring protein hormone that may improve metabolic function,33 reduce inflammation,34 and improve bone health,35 among other things