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Consequently, ICIs targeting PD-1/PD-L1, which are currently leading agents in cancer immunotherapy, have shown considerable clinical effectiveness, including in advanced cancer cases [111]

Even if these concerns are addressed, GBCA administration requires intravenous access, a requirement that places risks on patients and healthcare practitioners, as well as limiting its application in cases when contraindicated (Guo et al., 2018)

Therefore, gaining insights into the underlying mechanisms that control macrophage function in the tumor microenvironment is crucial for developing effective therapeutic interventions targeting macrophages in cancer

59 RoviraA.OrellanaP.Alvarez-SabnJ.ArenillasJ

Take breaks Cycle peptides (8-12 weeks on, 4+ weeks off) to avoid receptor desensitization 8