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The iron-rich milieu induces upregulation of the iron transporter DMT1 through two sequential mechanisms: First, unbound iron activates hypoxia-inducible factor-1 (HIF-1), which directly binds to the DMT1 promoter to enhance its transcription (Ingrassia et al
doi: 10.1016/j.taap.2011.03.017
doi: 10.3390/cells11010072 19 RoyJGalanoJMDurandTLe GuennecJYLeeJC
Dodge ML, Wander RC, Xia Y, Butler JA, Whanger PD
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