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Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis

Goal: Support metabolic efficiency through NNMT inhibition, potentially enhancing fat oxidation and NAD+ levels [1] [2]

Yes, split dosing is a valid approach, particularly for doses at the higher end of the range (450-500mcg daily)

Surgery scheduled for the duration of the trial, except for minor surgical procedures, in the opinion of the investigator