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Bone marrow HSPCs were depleted in mouse xenograft models and immunocompetent cynomolgus macaques, after 12 weeks of JSP191 treatment [42, 45]

Under external stress conditions, serotonergic neurons in the dorsal raphe nucleus (DRN) can be activated and release 5-HT

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At neutral pH, the absorbance peak decreased with time, suggesting gradual depolymerization of blue melanin (Supplementary Fig

Depending on the extent of endplate fracture and NP herniation the damage ranges from minor when only small fracture lines are evident to a virtual loss of the entire nucleus tissue to the vertebral bone