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It has been demonstrated that melatonin in skin cells is rapidly metabolized through indolic, kynuric, and P450-dependent pathways or via nonenzymatic processes induced by UVR or free radicals [21,22]

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10.1016/j.ymgme.2013.07.007 8
For example, membrane derived microvesicles (MVs) can be 500-1000 nm in diameter, so as large as lipid droplets[184,185]

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