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The concentration of leukotriene D(4) (LTD(4)), which is usually not detectable, was highly increased, whereas LTE(4), the major urinary metabolite in humans, was completely absent
Finally, cell death induced by IGF-1R inhibition may lead to the release of tumor-specific antigens (TSAs) that help to initiate and potentiate immune responses facilitated by immunotherapeutic agents
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