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Acid-base balance For cells and enzymes to function properly, the pH (a measure of acidity/alkalinity) of our blood and tissue fluid has to be kept within a strict range

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Oxidative stress produces multiple pathological products, such as Superoxide Dismutase (SOD), Malondialdehyde (MDA), etc., which cause damage to cellular macromolecules and most importantly, mutations in genomic DNA (Wang et al., 2018

Among the proteins with increased expression in ME/CFS were 3-hydroxybutyrate dehydrogenase type 1 (BDH1) and acetyl-CoA acetyltransferase 2 (ACAT2), both of which are integral to fatty acid metabolism and processing of ketone bodies

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