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2013;8:e64401

The foremost issue is toxicity to normal tissues

Studies on the mechanism of sulofenur and LY295501 toxicity: Effect on the regulation of cytosolic calcium in relation to cytotoxicity in normal and tumorigenic rat kidney cell lines

Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention

There's currently no established Tolerable Upper Intake Level (UL) for B12 due to insufficient scientific evidence