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For example, the phenotypes of mice that lack the LepRb isoform, such as db/db mice, are very similar to the phenotypes of mice lacking leptin, such as the ob/ob mice or those lacking all isoforms of LepR, such as the db 3J /db 3J mice 26

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Montagnani M, Bottalico L, Potenza MA, et al

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Thus, alterations in RTN chemoreceptor neuron function may contribute to apnea incidence in OSA patients by altering the apneic threshold itself or the eupneic proximity to the apneic threshold