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41,169,170 Differential diagnoses include entrapment neuropathies, infectious neuropathies, and inflammatory conditions

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Animal models, especially gene knockout and transgenic models, have played an indispensable role in mechanistic verification, confirming the causal relationship between key inflammatory mediators (e.g., TNF-) and testicular-penile damage in preclinical settings, and providing a preclinical platform for evaluating the efficacy of potential therapeutic agents (210)

This ensures that the total body store of creatine is maintained, as creatine used in body tissues can be replenished from the diet or de novo synthesis [11]