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TB-500 is the rate-limiting component due to its larger size

The authors confirmed that BPC-157s pleiotropic healing profile spanning angiogenesis, inflammation modulation, nitric oxide signalling, and tissue-specific repair makes it one of the most comprehensively studied peptides in the musculoskeletal tissue repair research field

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Early work focused on the hGH fragment 177191, which was later modified by adding a tyrosine residue, leading to the development of AOD 9604