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Oxidative stress and inflammatory reaction will damage oligodendrocytes to a certain extent, destroying the nerve myelin sheath and further affecting nerve conduction (Spaas et al., 2021)
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Howell SJ, Campone M, Corts J, Duhoux FP, Ross S, Morris T, et al

Additionally, NETs can indirectly affect the angiogenesis process by releasing pro-angiogenic factors and modulating immune cell functions [73, 142]

The brain retains a sense of calm clarity even as the primary effects of the medication diminish