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Description
Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells function and viability
Blockade of LAG-3 immune checkpoint combined with therapeutic vaccination restore the function of tissue-resident anti-viral CD8(+) T cells and protect against recurrent ocular herpes simplex infection and disease

Xanthine was suggested as an intermediate precursor because of purine structure similarities

FEBS J (2022) 289(24):781029

Molecular Endocrinology, 28(11), 18411854
