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B.ChangC

Conflict of interest EB and GT were employed by PharmaNutra S.p.A, Pisa, Italy

Yang K, Wang X, Song C, et al

Discussion Lumbar disc herniation (LDH) is a common and frequently occurring disease in the clinic that seriously endangers the physical and mental health of patients

The Caughey and Prusiner labs had both discovered that PIPLC, an enzyme that can cleave GPI anchors, would release PrP C , but not proteinase K-resistant PrP Sc , from the surface of prion-infected cells, thus implying that whereas PrP C could be found on the cell surface, PrP Sc was buried somewhere inside the cell [Caughey 1990, Borchelt 1990, Taraboulos 1990]