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Another protein of interest, SLC25A11, was also found to be upregulated in the PBMCs of ME/CFS patients compared with controls

Because chronic anxiety and stress hormones actively impair neurogenesis and synaptic plasticity

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TSIIA-NE ameliorated LPS-induced pulmonary ventilatory dysfunction and pathological changes through antioxidant (up-regulation of superoxide dismutase, glutathione peroxidase, down-regulation of malondialdehyde), anti-inflammatory (up-regulation of IL-10, down-regulation of TNF- and IL-17) and inhibition of glycocalyx degradation, as evidenced by a 1.4-fold and 1.9-fold increase in tidal volume and minute respiratory volume, respectively, a 32% decrease in the wet/dry lung weight ratio, and an improvement in arterial blood gas levels

doi: 10.1152/ajplegacy.1964.206.1.49