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In this regard, engineering metaphors such as the ones described here could prove to be invaluable in overcoming the barriers that biological complexity imposes on our ability to understand these systems

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For instance, mature OLs are relatively preserved following perinatal white matter injury (e.g., periventricular leukomalacia, hypoxic-ischemic encephalopathy) in response to inflammatory and/or hypoxic-ischemic damage, as opposed to late-stage OL progenitors being highly susceptible to oxidative stress-induced apoptosis 30

Mechanistically, previous studies have suggested that GSTA1 deficiency activates TNFRSF13B and c-FOS through the induction of reactive oxygen species (ROS) elevation, further transcriptionally regulating CHGA to produce a neuroendocrine phenotype

doi: 10.1038/s41593-020-00764-7 71 LiJ