cyanine glutathione Multiple GSH-depleting dimeric for photothermal-ferroptosis induction with NIR-II fluorescence visualization and renal clearance Glutathione Reduced with Cyclosome® Technology

In-vivo pharmacological study Animals Adult male Albino rats (150 20 g) were obtained from the breeding colony maintained at the animal house of the Egyptian Drug Authority (EDA, Cairo, Egypt)

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Clinical presenting features of the condition include those relating to anaemia (e.g., pallor, weakness, and fatigue), gastro-intestinal symptoms (e.g., epigastric pain and glossitis), neurological symptoms (e.g., from numbness of extremities and impaired proprioception in subacute combined degeneration of the spinal cord to severe developmental delay, epilepsy, and coma in inherited intracellular cobalamin defects), psychiatric disturbances and neural tube defects in the newborn of a deficient mother (Molloy et al., 2009)

Hence, we chose only a single concentration of QCT (2 mg/kg) based on a prior study 44 , a relatively low dose compared to the commonly used range of 10100 mg/kg 45,46 , for our in vivo experiments

NF-B1, Nuclear factor B1