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The combination of the lysosome disruptor siramesine and the tyrosine kinase inhibitor lapatinib increased the expression of TF and reduced the expression of FPN1 in breast cancer cells, thereby promoting iron overload in the lysosome and ultimately inducing ferroptosis ( Ferroptosis could be induced by directly supplementing the cell's active iron pool to establish an iron overload state

At the mitochondrial level, ROS can easily induce oxidative damage to mtDNA, resulting in mtDNA mutations and the activation of the cGAS-STING innate immune pathway (113)

doi: 10.1016/j.cyto.2023.156144 185 Sharifi-RadJRayessYERizkAASadakaCZgheibRZamWet al

Libby P

2021ZYB003) from Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, and Innovative research team of high-level local universities in Shanghai