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doi: 10.1093/nar/gkaa1154 [DOI] [PMC free article] [PubMed] [Google Scholar] 21

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132 Concurrently, ROS, particularly OH, initiate lipid peroxidation by attacking polyunsaturated fatty acids (PUFAs) within cellular membranes

GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)

While numerous compounds have demonstrated efficacy in vitro and in murine models, no phase I or II trials directly targeting NRF2 have been conducted in HCC patients, raising concerns about their applicability in clinical practice