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Biomedicines 10:2053

Furthermore, NCs exert cell cycle arrest, either at the G0/G1 or G2/M phase, while also inhibiting the genes for proliferation and suppressing oncogenic signalling pathways such as PI3K/Akt, MAPK, JAK/STAT3, NF-B, mTOR, and Wnt/-catenin

Higher initial doses can be required in patients with prior opioid

Increased mtROS generation may contribute to IR and drive the progression of NASH and MASLD [196, 197]

doi: 10.1016/j.ijpharm.2024.124223 43 DarraA.SinghV.JenaA.PopliP.NadaR.GuptaP.et al
