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Thus, the adalimumab preparation containing citrate buffer (7.3 mM) differed from the citrate-free one in volume (0.8 ml vs 0.4 ml), needle diameter (27 G vs 29 G) of prefilled syringes used for the administrations, and excipients [42]

Therefore, glycocalyx damage not only manifests as local pathologic changes in the organ but is also likely to be one of the common pathologic mechanisms for the progression of SAP to MODS

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