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Symptomatic treatment for PAD adds maximal risk factor modification, exercise, and, when indicated, invasive treatment using balloon angioplasty with or without stenting and bypass surgery together
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However, the evidence is limited and the effect size is small
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Moreover, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated Na + /Cl influx further disturbs osmotic balance, contributing to cytotoxic edema, a process blocked by AMPA antagonists (e.g., perampanel) in rodent models [139, 140]
