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Agrawal, S

CYP is expected to have two modes of action: it easily crosses and accumulates in biological membranes leading to stimulate the production of ROS and result in oxidative damage to essential cell components caused by oxygen-free radicals (Khanna et al

However, iron chelators including deferoxamine (DFO), deferiprone (DFP), and deferasirox (DFX) generally lack tissue and cellular specificity, often resulting in the non-selective depletion of physiologically essential iron

No mutagenic or genotoxic effects have been reported